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desvenlafaxine will increase the level or outcome of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment necessary with desvenlafaxine doses 7 consecutive days quickly bef